Advances in computationally modeling human oral bioavailability
نویسندگان
چکیده
منابع مشابه
Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability
Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...
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This chapter presents a survey of the most recent vision-based human body modeling techniques. It includes sections covering the topics of 3D human body coding standards, motion tracking, recognition and applications. Short summaries of various techniques, including their advantages and disadvantages, are introduced. Although this work is focused on computer vision, some references from compute...
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In the development of drugs intended for oral use, good drug absorption and appropriate drug delivery are very important. Now the predictions for drug absorption and oral bioavailability follow similar approach: calculate molecular descriptors for molecules and build the prediction models. This approach works well for the prediction of compounds which cross a cell membrane from a region of high...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2015
ISSN: 0169-409X
DOI: 10.1016/j.addr.2015.01.001